Interestingly, the in vivo experiments performed in immunosuppressed mice implanted with HT29 (KRAS WT), LS180 (heterozygous 12D/WT) or SW480 (homozygous 12 V) CRC cells, demonstrated that SW480 line was the most sensitive to the KR12 treatment since a marked inhibition of tumor growth was observed, while only a slight or no antitumor effect was observed on LS180 or HT29 models, respectively. Here, KRAS is linked to neoplasm.