Furthermore, in a series of well-characterized tumour cell line derived from sequential stages of mouse skin carcinogensis, activated H-Ras over-expression in squamous carcinoma cells demonstrate that Ras stimulates TGF-β-induced transcription and enhances TGF-β-induced phosphorylated Smad2 levels [10]. The gene discussed is TGFB1; the disease is squamous cell carcinoma.