Recently, Liu et al., [29] reported that expression of Smurf2 is associated with the ER, PR, and HER2 status of breast tumors, which instigated us to analyze the crosstalk between Smurf2 and CNKSR2 expression with the hormonal (ER and PR) and HER2 status of breast tissue samples. This evidence concerns the gene SMURF2 and breast neoplasm.