Recent reports by Jin et al., 2009 highlighted the importance of Smurf2 proteins in breast cancer [14]; therefore to study the functional role of Smurf2 and CNKSR2 in human breast cancer tissues, we initially analyzed the expression levels of Smurf2 and CNKSR2 proteins in eight matched-sets of primary mammary carcinoma (Invasive Ductal Carcinoma, IDC) and adjacent normal breast tissue samples by western blotting. This evidence concerns the gene SMURF2 and invasive ductal breast carcinoma.