In addition to Smurf2 and CNKSR2, we also analyzed the ER, PR, and HER2 status of the 84 representative cases, provided along with the tissue microarray data by Pantomics, and observed that only 14.29% of DCIS and 14.55% of IDC’s showed intense expression of ER compared to the normal and fibrocystic tumors (0.00%) (P < 0.001). Here, SMURF2 is linked to ductal breast carcinoma in situ.