We reported previously that Smurf2 knockdown significantly downregulated the CNKSR2 protein levels in MDA-MB-231, MCF-7, SW480, and SCC131 cancer cell lines without any effect on CNKSR2 mRNA, suggesting that Smurf2 controls the CNKSR2 protein level possibly through proteolytic regulation. Here, CNKSR2 is linked to cancer.