Most of the normal/hyperplasia (75.00%) and fibrocystic cases (57.14%) showed only a mild expression of CNKSR2, whereas the intensity of CNKSR2 expression increases with progression in tumor grade with 14.29% of fibroadenomas, 42.86% of DCIS and 52.73% of IDC’s showing intense expression of CNKSR2. This evidence concerns the gene CNKSR2 and ductal breast carcinoma in situ.