Moreover, in acetic acid-induced acute colitis rat models, oral administration of hydro-alcoholic extract from M. oleifera seeds (MSHE) at three increasing doses (50, 100, and 200 mg/kg) can reduce distal colon weight as a marker of inflammation and tissue edema, ulcer and mucosal inflammation severity, crypt damage, invasion involvement, total colitis index, and myeloperoxidase (MPO) activity when compared with the untreated groups [18]. This evidence concerns the gene MPO and colitis.