In particular, the p.Thr594Met substitution was highly prevalent in a large population of black African origin, its frequency increased with the severity of hypertension [77] and was significantly associated with low plasma renin activity [76].The association of α ENaC polymorphisms (rs2228576, rs11542844, rs3741913) (resulting in the substitutions p.Thr663Ala, p.Ala334Thr and p.Cys618Phe) have been associated with high blood pressure in some studies, but not in others [79]. This evidence concerns the gene REN and hypertensive disorder.