INS and diabetes mellitus: However, in a pooled analysis of 450 patients with diabetes, Viguiliouk et al. (2014) [43] reported lower fasting glucose (mean difference (MD) = −0.15 mmol/L (95% CI: −0.27, −0.02); p = 0.03), but no effect on fasting insulin or HOMA-IR with a median dose of 56 g/day for 8 weeks.