Taking in mind that our previously enrolled population [11] was at high cardiovascular risk with an indication to undergo coronary angiography for suspected myocardial ischemia, if we consider only nondiabetic patients, the presence of normal coronary arteries seems to depend mostly on the presence of a particular genetic variant of KCNJ11 rather than other cardiovascular risk. The gene discussed is KCNJ11; the disease is myocardial ischemia.