NR1H3 and metabolic dysfunction-associated steatotic liver disease: It has been also found that diosgenin increases the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in HepG2 cells, furthermore it suppresses LXRa in a rat model of non-alcoholic fatty liver disease (NAFLD), thus preventing development of NAFLD [48].