IGF1R and cancer: On the other hand, selenol-disubstituted pyrido[2,3-d]pyrimidine (33) and quinazoline (34) derivatives were proposed as promising candidates against cancer and other diseases: they are capable to produce a potent activation of the insulin-like growth factor 1 receptor (IGF-1R), playing thus a major role in cancer growth, tumor cell survival and resistance to therapy [75].