In cell lines where TXNIP expression was silenced, 1,25(OH)2D3 did not appear to induce the expression of the protein, whereas in cell lines that expressed TXNIP at varying degrees, 1,25(OH)2D3 exerted either the expected “classical” induction, for example in U937 (histiocytic lymphoma), or non-canonical reduction, as observed in LNCaP, BxPC-3, and MCF-7 (prostate, pancreatic, and breast cancer cells, respectively), but also had no clear effect on TXNIP levels, like in HT-29 cells (colorectal cancer) (Figure 1). The gene discussed is TXNIP; the disease is breast cancer.