Moreover, the results question the role/importance of TXNIP in mediating 1,25(OH)2D3’s anti-cancer effects since in cell lines where TXNIP levels are reduced by 1,25(OH)2D3, such as LNCaP and MCF-7, treatment has been shown to induce profound anti-tumor actions [32,33,34]. The gene discussed is TXNIP; the disease is neoplasm.