TXNIP and breast cancer: The investigated cell lines exhibited disparate basal levels of TXNIP, where some cell lines had completely repressed TXNIP expression, with the colorectal cancer cell line HCT116 as an example, some cell lines had high basal expression of the protein, like the breast cancer cell line MCF-7, and finally, cell lines with lower TXNIP levels, like the pancreatic cancer cell line AsPC-1 (Figure 1).