TXNIP and cancer: To investigate whether 1,25(OH)2D3 is capable of inducing TXNIP expression in different cancer models, cell lines of various tissue origins—hematological, prostate, pancreatic, liver, colorectal, and breast—were treated with either DMSO or 1,25(OH)2D3 (100 nM) for 72 h and TXNIP levels were analyzed using immunoblotting.