For example, functionality of the dominant MAIT cell population in the liver is impaired in cirrhosis.36 This cell type can secrete potentially potent IFNγ following stimulation by IFNα.37 Rescue of responses in these resident populations through a boost of local IFNα may lead to amplified intrahepatic effectors crucial in clearance of residual infection. This evidence concerns the gene IFNA1 and infection.