In light of the interactions of innate immune cells, particularly macrophages, in tumor development, progression, and metastasis [42–48], and possible roles of FOXQ1 in regulating these processes [49,50], we generated gene knockouts of the two zebrafish orthologs (foxq1a and foxq1b) of human FOXQ1 using CRIPSR-Cas9 targeted mutagenesis. This evidence concerns the gene FOXQ1 and neoplasm.