When stratifying according to ethnicity, greatly affected cancer susceptibility associations between the TERT rs2853669 polymorphism and cancer susceptibility were observed in Asians in the allelic comparison (C vs. T: OR = 1.248, 95% CI = 1.035–1.505; P = 0.020), homozygote comparison (CC vs. TT: OR = 1.590, 95% CI = 1.183–2.135; P = 0.000) and recessive model (CC vs. CT + TT: OR = 1.442, 95% CI = 1.190–1.746; P = 0.000), but not for Caucasians in any of the genetic models. The gene discussed is TERT; the disease is cancer.