In this study, we also demonstrated that CacyBP/SIP is translocated from the cytoplasm to the nuclei in response to elevated intracellular Ca2+ by ionomycin in colon cancer SW480 cells and is re-translocated from the nuclei to the cytoplasm by decreasing the intracellular [Ca2+]i with BAPTA. Here, CACYBP is linked to malignant colon neoplasm.