PROM1 and cryohydrocytosis: Among the 13 studied miRNAs, only miR-101 was significantly up regulated (fold change = 1.69 P value = 0.016) while miR-122 was significantly down regulated (fold change = -1.74 P value = 0.0114) upon comparing CD133+ cells of the CHC group to those of the control group as shown in S1 Table and Fig 2A.