PROM1 and laryngotracheoesophageal cleft: Moreover, miR-22 and miR-101 were significantly up regulated (fold change = 2.4 & 2.7 P value = 0.000002 &0.0002 respectively) whereas miR-122, miR-192, miR-885-5p, miR-224, miR-125a-5p and miR-199a-3p were significantly down regulated (fold change = 0.36, 0.25, 0.55, 0.33.0.66 & 0.03 P value = 0.000009, 0.005, 0.011, 0.015, 0.000001 & 0.03 respectively) on comparing CD133+ cells of the LC group to the control group as shown in S2 Table and Fig 2B.