Our results revealed that miR-181b, miR-602, miR-101, miR-122, miR-192, miR-125a-5p miR-221 and miR-22 were significantly up regulated up on comparing CD133+ cells of the HCC group (PB) to those of the control group (PB). The gene discussed is PROM1; the disease is hepatocellular carcinoma.