Moreover, miR-125a inhibits the invasion of HCC cells through regulating the PI3K/AKT/mTOR pathway [39]. However, the significant up-regulation of miR-125a-5p in this study came in agreement with an early report by Guo et al. who proved that miR-125a alone was capable of increasing the number of hematopoietic stem cells in vivo via targeting multiple proapoptotic genes e.g. Bak1[40]. In addition, ERBB2 and ERBB3 were negatively regulated by miR-125a and miR-125b. The gene discussed is BAK1; the disease is hepatocellular carcinoma.