On comparing CD133+ cells of the HCC group (PB) to those cells of the control group (PB); miR-122, miR-192, miR-885-5p, miR-224, miR125a-5p, miR-181b and miR-199a-3p were significantly up-regulated whereas miR-22 was significantly down-regulated. This evidence concerns the gene PROM1 and hepatocellular carcinoma.