Among the 13 studied miRNAs in CD133+ cells of the HCC group compared to the CHC group; miR-602, miR-122, miR-181b, miR-125a-5p and miR-192 were significantly up regulated (fold change = 13, 3.1, 2.8, 1.6 & 1.56 P value = 0.01, 0.001, 0.000004, 0.002 & 0.007; respectively) as shown in S4 Table and Fig 4A. This evidence concerns the gene PROM1 and hepatocellular carcinoma.