In the context of the Hippo pathway, SSOs could be used to affect splicing of the TEAD4 gene in relevant cancers, causing skipping of exon 3 to produce the truncated tumour suppressor variant TEAD4-S (Figure 3B), which has been shown to suppress tumour growth in vivo and has been associated with improved survival in lung and colon cancer patients [65]. This evidence concerns the gene TEAD4 and malignant colon neoplasm.