The AMPK:HIF-1:ROS circuit predicts that cancer cells can acquire three stable phenotypes, a glycolysis phenotype characterized by high HIF-1 and low AMPK activities, an OXPHOS phenotype characterized by low HIF-1 and high AMPK activities and a hybrid glycolysis/OXPHOS metabolic phenotype, characterized by both high HIF-1 and high AMPK activities (Figure 4B). The gene discussed is HIF1A; the disease is cancer.