Notably, exosomes released by CD99-silenced Ewing sarcoma cells contain higher levels of miR34a than their parental counterparts and successfully downregulate Notch 1 and Notch 3 expression, as well as causing NF-κB transcriptional activity in recipient Ewing sarcoma cells, which in turn differentiate toward a neural phenotype [74]. The gene discussed is NOTCH3; the disease is Ewing sarcoma.