IL10 and Hepatic fibrosis: In the context of liver fibrosis, Thomas et al. [125] reported that the infusion of bone marrow derived macrophages into the hepatic portal vein of mice after liver injury resulted in the upregulation of MMPs 9 and 13, which participate in the process of hepatic scar tissue remodelling, and led to paracrine effects via elevated anti-inflammatory IL-10 levels.