Moreover, the role of mitochondrial CB1R was further expanded by several recent observations suggesting its association with cannabinoid-induced feeding behavior in hypothalamic proopiomelanocortin (POMC) neurons, memory impairment in hippocampus, and neuroprotection after cerebral ischemia/reperfusion injury [81,82,83]. The gene discussed is POMC; the disease is Cerebral ischemia.