It is well‐known that EGFR and its downstream signal pathways, including PI3K/AKT/mTOR pathway and Raf/MEK/Erk pathway, play key roles in many types of tissue cell tumorigenesis and tumor progress and metastasis, and are also important in regulating body immunity in suppressing T cell induced specially tumor necrosis via decreasing the expression of PD‐L1 25, 26, 31. This evidence concerns the gene MAP2K7 and neoplasm.