Activation of FOXOs (such as FoxO1 in prostate cancer cells) triggers cell cycle arrest and induces cell apoptosis via increasing the levels of Fas‐L (Fas ligand), TRAIL (tumor necrosis factor‐related apoptosis‐inducing ligand), and Bim in various types of cells 10. This evidence concerns the gene BCL2L11 and Familial prostate cancer.