Finally, cell growth inhibition, cell autophagy, and apoptosis were induced by CFF‐1 in prostate cancer cells via down‐regulating the levels of Cyclin D1/Bcl‐2/XIAP/Survivin and up‐regulating the levels of p21/p27/Bax/FasL/Bim/c‐Caspase 3/c‐PARP‐1/LC3‐II/Beclin‐1. The gene discussed is FASLG; the disease is prostate cancer.