It is reported that FOXO1 was a tumor suppressor and over‐activation of FOXO1 could induce cancer cell apoptosis not only by stimulating expression of death receptor ligands, like FasL (Fas ligand) and TRAIL (tumor necrosis factor‐related apoptosis‐inducing ligand), but by inducing expression of multiple pro‐apoptotic Bcl‐2 family members (mitochondria‐targeting proteins), like Bim 10. The gene discussed is BCL2; the disease is neoplasm.