Moreover, as reported in previous studies, an association between accelerated fetal growth and ALL risk is biologically plausible, involving the participation of fetal growth factors, for example, insulin‐like growth factor‐1 (IGF‐1) and IGF‐2, and IGF‐1R receptors, IGF‐2R and its major binding protein‐3 (IGFBP‐3), which have been recognized as crucial in mediating the effect of growth hormones 47, 48, 49. The gene discussed is IGFBP3; the disease is acute lymphoblastic leukemia.