In the same time, significant differences in circulating immune cells and inflammatory proteins such as fibrinogen(Fib), albumin(Alb), and pre‐Alb(pAlb) were commonly observed in LC patients comparing to healthy individuals, and circulating neutrophil, lymphocyte, and platelet and those proteins were candidate biomarkers to reflect the status of chronic inflammation and to evaluated prognosis of the disease 6, 7, 8. This evidence concerns the gene FBL and laryngotracheoesophageal cleft.