Above all, as few studies systematically incorporated ciRS‐7, miR‐7 and NF‐κB regarding their functions for NSCLC onset, this study was aimed to unravel whether ciRS‐7 secreted by exosomes would alter NSCLC development via regulation of downstream miR‐7 and NF‐κB signalling. Here, NFKB1 is linked to non-small cell lung carcinoma.