As we previously found that, in APL‐derived cells, Vav1 regulates the presence of PU.1 on its consensus region on the miR‐142‐3p promoter,23 our subsequent aim was to assess whether, also in regulation of miR‐29b, the PU.1 action is supported by Vav1. The gene discussed is SPI1; the disease is acute promyelocytic leukemia.