Interestingly, in Kasumi‐1, in contrast to NB4, we found the presence of Vav1 in the molecular complexes on the PU.1 consensus region on miR‐29b promoter, evidencing for the first time the direct participation of Vav1 to the transcriptional machinery in non‐APL cells. Here, SPI1 is linked to acute promyelocytic leukemia.