Despite the use of ATRA in non‐APL cells was ineffective in terms of differentiation and/or apoptosis,31 we first used this agonist to induce the expression of PU.1 in Kasumi‐1 cells, on the basis of its role on miR‐29b transcription in NB4 cells. Here, SPI1 is linked to acute promyelocytic leukemia.