CALCA and migraine disorder: The title of the EHF Lecture was inspired by the famous allegorical woodcut “The Great Wave of Kanagawa” by Katsushika Hokusai (1760-1849) with the idea of two recent scientific and clinical phenomena that made calcitonin gene-related peptide (CGRP) popular in migraine research: first, the wave of CGRP that may flush our head during a migraine attack, and second, the hype about new options in migraine therapy by blocking the CGRP system.