Therefore, the αvβ6 integrin is an attractive therapeutic target for IPF with the advantage of inhibiting disease-specific activation of TGFβ via αvβ6, while limiting the potential for toxicological effects that may be associated with direct inhibition of TGFβ, that includes heart valve lesions and physeal dysplasia [12]. The gene discussed is TGFB1; the disease is idiopathic pulmonary fibrosis.