CD8A and breast neoplasm: A CD8 + lymphocyte infiltrate is a good prognostic feature in basal-like cancers20,21 and further evidence is emerging that lymphocytic infiltration may risk stratify patients.22 It has become apparent that a subset of ER − breast tumours, including those that belong to IntClusts 4 and 10, are associated with a significant immune response conferring better outcome.