BIX also generated intracellular ROS in human renal carcinoma Caki cells (Fig. 5a), but ROS scavengers were not affected by combined treatment with BIX and TRAIL and BIX-mediated modulation of XIAP, survivin, and DR5 expression (Figs. 5b, c). The gene discussed is TNFRSF10B; the disease is renal carcinoma.