After 7 days of permanent coronary ligation, compared with control mice, mice injected with lv3-siNR4A2 exhibited enlarged hearts (Fig. 1d), and lv3-siNR4A2 increased the expression of the apoptosis markers poly(ADP-ribose) polymerase (PARP) and caspase3, as well as the autophagy marker LC3 (Fig. 1e, f), suggesting that NR4A2 knockdown aggravates MI-induced heart injury. Here, MAP1LC3A is linked to myocardial infarction.