The client proteins tested include Tau, a microtubule binding protein implicated in Alzheimer’s disease17, poly-glutamine-containing ataxin3 known to be involved in spinocerebellar ataxia 3 (SCA3)18, amyotrophic lateral sclerosis-associated SOD119 and TDP4320, 21. The gene discussed is MAPT; the disease is Machado-Joseph disease.