In a previous report, we found that troponin and BNP were strongly predictive of CVD mortality but not for non-CVD mortality, and we suggested that biomarkers should be examined for specific causes of mortality in cohort studies.15 With the exception of total cholesterol and Lp-a and fatal and non-fatal MI/IHD, none of the other panel of biomarkers, including several inflammatory markers, showed convincing associations with the individual cardiovascular outcomes in this subcohort of men. Here, NPPB is linked to myocardial ischemia.