Of the remaining biomarkers, only the lipids total cholesterol and Lp-a and the liver enzyme aspartate transaminase showed significant associations with either acute MI/IHD or stroke (for acute MI/IHD the top third SHR was 2.48 (95% CI 1.63 to 3.77) for total cholesterol and 1.84 (95% CI 1.26 to 2.69) for Lp-a; for aspartate transaminase, the respective SHRs were 0.68 (95% CI 0.46 to 0.99) for acute MI/IHD and 0.63 (95% CI 0.41 to 0.96) for stroke. The gene discussed is LPA; the disease is myocardial ischemia.