RET and neoplasm: VHL/SDHx transcription profile is linked to the angiogenesis, hypoxia and a reduced oxidative response through stabilizing HIF-a that is a transcription factor with important role in apoptosis, angiogenesis, energy metabolism, proliferation, migration and invasion of tumor cells(87, 88).RET/NF1 cluster cover genes concerned in initiation of translation, protein synthesis and kinase signaling(90) and is linked to the activation of the RAS/RAF/MAPK pathway and the PI3/AKT signaling pathway(87).