BCL2 is overexpressed in almost all types and subtypes of hematological malignancies, indicating the importance of this molecule in disease pathogenesis and evolution(16).The over-expression of B-cl2 is a highly characteristic and specific indicator of follicular lymphoma, and B-cl2 is a potentially useful diagnostic tool in sub-classification and prognosis of low-grade B-cell lymphomas(16).Bcl-2 is the founding member of a family of apoptosis-regulating proteins whose interactions are the final regulatory step before the irreversible commitment to apoptosis. The gene discussed is BCL2; the disease is hematologic disorder.