This was in agreement with previous studies (13,19,20).The concomitant accumulation of p53 protein in high grade lymphomas may lead to mutant p53 protein binding to the transcriptional silencer within the Bcl-2 promoter and therefore downregulating Bcl-2 protein expression(21),a phenomenon that explains the pattern of Bcl2 expression in NHL. The gene discussed is TP53; the disease is lymphoma.