Hence, the expression of bcl-2, other bcl-2 family members (e.g, bcl-XL, BAX), and apoptosis regulators are altered in HL(25).The altered expression of these proteins in HRS cells may prevent apoptosis caused by the absence of functional B-cell receptor and explain resistance to treatment-induced apoptosis and treatment failure(26).The prognostic value of Bcl-2 in CHL has been examined andBcl-2 has been found as an independent factor that predicts poor prognosis when considered together with clinical variables (27). Here, BAX is linked to classic Hodgkin lymphoma.