Comparison between Bcl-2 and Bax staining showed a statistically significant relationship for co-expression cases or absence of expression of both proteins in RS cells in a study by Knavaros et al. (29).Reduced Bax expression was attributed to post-transcriptional regulation with lack of Bax immunosuppression, providing immunohistocemical evidence for deregulated expression of cell cycle and apoptotic related proteins, which may play a role in pathogenesis of HD. Here, BAX is linked to Huntington disease.