SPHK1 and neoplasm: Evidence determined that SPHK1 has oncogenic manner, which highlighted it as oncogenic enzyme (15), and can be a chemotherapeutic target because of its oncogenic characteristic and high expression of this gene and its product, S1P depends on many growth factors, which leads this gene and S1P toward stimulatory effects on tumor angiogenesis and cell motility that are critical for metastasis (10).