Sphingosine kinases (SphKs) are introduced as unique regulators that produce S1P and decrease other metabolites (9).Anti-apoptotic lipid, S1P, is synthesized by SphKs, especially Sphingosine kinase 1 (SPHK1).Two distinct is of orms are known for SphKs; SPHK1 that regulates the essential processes of cancer progression, and SPHK2 that is much less known about its biological actions in cancer. The gene discussed is SPHK2; the disease is cancer.