High expression of SPHK1 is detected in multiple types of cancers, which can be associated with tumor angiogenesis and resistance to radiation and chemotherapy(10).SPHK1,as a cytosolic enzyme, is stimulated by binding multiple growth factors through their tyrosine kinase receptors (RTKs) to produce higher S1P (10, 11). The gene discussed is SPHK1; the disease is cancer.