Various molecular genetic abnormalities are detected in 12q in different subtypes of liposarcoma including t(12;16)(q13;p11), or t(12;22)(q13;q12) translocations, which lead to fusion of transcription factor gene CHOP (DDIT3) (a negative regulator of adipocyte differentiation) with TLS (FUS) or EWS genes in at least 95% of MLS cases, as well as amplification of 12q13-15 encompassing MDM2 and CDK4 genes in well-differentiated and dedifferentiated liposarcomas(24). This evidence concerns the gene MDM2 and liposarcoma.