TamKi et al. performed a comprehensive study on 353 breast cancer patients, using clone 6F11 (Ventana, Tucson, AZ, USA), clone 6 Ab (Ventana), and a standard immunohist-ochemistry(IHC) kit (Hercep Test for Immunoenzymatic Staining; Dako, Denmark)for ER,PR, and Her-2. Here, ESR1 is linked to breast cancer.