Additionally, with the inclusion of the entity “high grade B-cell lymphoma, with MYC and BCL2 or BCL6 rearrangements” in the WHO 2016 lymphoma classification, it also becomes critical to perform FISH to exclude a MYC gene rearrangement in cases of lymphoma with DLBCL morphology2. The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.