Serum chemistry analyses after Toc-HDO (No. 1) injection showed severe liver dysfunction (as evidenced by elevated levels of total bilirubin, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase), which worsened with the increase in the injected dose, and mild renal dysfunction (Supplementary Table S3). Here, GPT is linked to Abnormal renal physiology.