The top five canonical MetaCoreTM pathways enriched across the set of all cancer-associated NLG variations (including both LOG- and GOG-causing variants) include muscle contraction GPCRs in the regulation of smooth muscle tone (P = 2.120e-09), signal transduction mTORC2 downstream signaling (P = 1.058e-8), development regulation of epithelial-to-mesenchymal transition (EMT) (P = 1.477e-8), breast cancer (general schema) (P = 9.996e-8), and nociception nociceptin receptor signaling (P = 1.259e-7). The gene discussed is OPRL1; the disease is breast carcinoma.