HRH1 and cancer: Similarly, the top five LOG somatic variants include signal transduction_mTORC2 downstream signaling (P = 4.862e-11), development_regulation of epithelial-to-mesenchymal transition (EMT) (P = 1.985e-8), cell adhesion_histamine H1 receptor signaling in the interruption of cell barrier integrity (P = 2.192e-8), cell adhesion_cadherin-mediated cell adhesion (P = 4.214e-8), and some pathways of EMT in cancer cells (P = 1.002e-7).