We observed the NOTCH1 A465T variant in colon cancer [DOID:219], malignant glioma [DOID:3070], esophageal cancer [DOID:5041], head and neck cancer [DOID:11934], pharynx cancer [DOID:0060119], and brain cancer [DOID:1319]. Here, NOTCH1 is linked to brain cancer.