Another de novo variant was found in the PC gene, which maps to 1 of the 30 loci with significant BD association from the second Psychiatric Genomics Consortium GWAS (rs7122539, p = 3.80E-08)54, and produces a protein, which catalyzes the carboxylation of pyruvate to oxaloacetate, and is involved in insulin secretion and synthesis of the neurotransmitter glutamate. Here, INS is linked to Behcet disease.