ESR1 and breast cancer: eQTL analysis of the remaining 26 loci (69 protein-coding genes) identified 22 SNP-gene combinations that were nominally significant (t-test P < 0.05) in all, ER+ or ER− breast cancers (Supplementary Data 6), nine of which remained significant after taking account of multiple testing (FDR adjusted t-test P < 0.1,Table 3).