ESR1 and breast carcinoma: The 11p15.5-rs3817198 risk locus, which is associated with ER+ breast cancer forms multiple interaction peaks in the ER− breast cancer cell lines, but not in the ER+ breast cancer cell lines or in Bre80 (Fig. 3a, Supplementary Data 2) and the 6q25.1-rs2046210 (ESR1) locus, which has been shown to be preferentially associated with ER− breast cancer20,23 forms interaction peaks in the ER+, but not the ER− breast cancer cell lines (Fig. 3b, Supplementary Data 2).