However, for both 14q24.1-rs2588809 (ZFP36L1) and 19p13.1-rs8170 (MRPL34) the rare alleles are associated with lower levels of expression (Fig. 5g, i) and higher risk26; lower levels of expression are also associated with a poor outcome (Fig. 5h, j) consistent with these genes acting as tumour supressors influencing both predisposition and outcome similarly. The gene discussed is MRPL34; the disease is neoplasm.