NLRP3 inflammasome has also been involved in chronic inflammation‐associated complex diseases, including T2D (Martinon et al, 2006; Duewell et al, 2010; Masters et al, 2010; Zhou et al, 2010; Wen et al, 2011; Heneka et al, 2012; Lamkanfi & Dixit, 2012; Broderick et al, 2015), suggesting the possibility to reverse these diseases by inhibition of NLRP3 inflammasome‐dependent inflammation. The gene discussed is NLRP3; the disease is type 2 diabetes mellitus.