Since lack of CREB3L1 expression results in increasing expression of PTN to positively regulate angiogenesis and facilitate the growth of tumors [7], it is very likely that a combining measure of the CREB3L1 and PTN gene levels in gliomas would be advantageous to a single examination in understanding malignant features of the tumors in clinical practice. This evidence concerns the gene CREB3L1 and glioma.