MED12 and schizophrenia: In humans, mutations in MED12 cause two, rare, intellectual disability syndromes called FG syndrome and Lujan-Fryns (LF) syndrome, while in-frame insertions and deletions in MED12 are associated with a 1.8-fold increased risk of schizophrenia (Wu et al., 2014; Risheg et al., 2007; Schwartz et al., 2007; DeLisi et al., 2000).