The important relevance of these studies to uveitis (Boldison et al., 2014; Chen et al., 2012; Copland et al., 2012; Oh et al., 2011; Raveney et al., 2008) is that re-programming under chronic inflammation remains a dynamic process at late stages of disease, with recirculation of CD4+ cells, changes in the composition of infiltrating immune cells and changes in their rates of recirculation. The gene discussed is CD4; the disease is uveitis.