TLR9 and infection: UNC93B1 can facilitate trans-location of TLR (TLR3, TLR7 and TLR9) from the endoplasmic reticulum to the Golgi [51, 52] and mediates the host immune responses to infection with murine cytomegalovirus [53], as well as several intracellular protozoan parasites [35, 54].