ACTA2 and marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections: Future studies also have to investigate whether the observed miRNA expression profiles are specific to MFS or also relate to other syndromes with familial thoracic aortic aneurysm like Loeys–Dietz syndrome, Shprintzen–Goldberg syndrome or mutations in ACTA2.