To figure out whether DESC1 inhibited chemotherapy resistance of ESCC cells via EGFR/AKT, EC9706 or KYSE30 cells were transfected with si-NC, si-DESC1, si- DESC1 + DMSO, and si-DESC1 + AST1306 (EGFR inhibitor) [24]. Here, AKT1 is linked to esophageal squamous cell carcinoma.