PTEN and hepatocellular carcinoma: To further confirm that miR-32-5p induces multidrug resistance by targeting PTEN in HCC, we transfected siPTEN and PTEN-expressing vector into Bel7402 and Bel/5-FU cells, MTT results showed that the reduction of PTEN led to multidrug resistance compared with siRNA NC; however, ectopic expression of PTEN reduced multidrug resistance compared with vector control (Fig. 4b).